| Investigador | Josué Ernesto Rosendo Rentería |
| Nombre de la institucion | Springer International Publishing |
| Nombre de la Subdireccion | |
| Nombre de la Gerencia | |
| Fuentes | S/D |
| Descripción | The Santiago River is one of the most contaminated rivers in Mexico, with heavy metal levels above the allowed limits. Scientific evidence indicates that chronic heavy metal exposure leads to cytogenotoxic effects. The aims of this study were to evaluate the genotoxic and cytotoxic effects of such exposure in buccal mucosa cells by micronucleus (MN) assay and to identify other nuclear abnormalities (NAs), such as nuclear buds (NBUDs), binucleated cells (BNs), pyknotic nuclei (PNs), karyorrhexis (KX), karyolysis (KL), and abnormally condensed chromatin (CC). Assays were performed on samples from four populations located alongside the Santiago River that are under chronic exposure to heavy metals and other metals (HMMs), and the results were compared with those of a population without exposure to HMMs. The exposed group showed increased frequencies of NAs (KX, CC, and KL), which are associated with cytotoxic damage, and NBUDs, which are associated with genotoxic damage. Increased frequencies of NBUDs and CC were observed in subjects from El Salto/ Juanacatlán, Ocotlán, and Paso de Guadalupe, and an increase in KX frequency was observed in subjects from El Salto/Juanacatlán. Significant differences in KL frequency were observed in subjects from La Barca, El Salto/Juanacatlán, Paso de Guadalupe, and Ocotlán. Predictors for increased development of MNs and NBUDs were high concentrations of Al, Zn, and Cu. In conclusion, chronic exposure to HMMs, especially Al, Cu, and Zn, in the studied population could be related to increased frequencies of NAs, such as NBUDs, KX, CC, and KL, in the buccal mucosa cells. |
| Objetivo | The aims of this study were to evaluate the genotoxic and cytotoxic effects of such exposure in buccal mucosa cells by micronucleus (MN) assay and to identify other nuclear abnormalities (NAs), such as nuclear buds (NBUDs), binucleated cells (BNs), pyknotic nuclei (PNs), karyorrhexis (KX), karyolysis (KL), and abnormally condensed chromatin (CC). |
| Fecha de consulta | |
| Tipos de usuarios | Academia |
| Identificacion de usuarios | Sí |
| Área responsable de la publicación | Springer International Publishing |
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| Metodología | No |
| Liga de acceso a la metodología | |
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| Fecha de último levantamiento de información | 9/20/2017 |
| Actualización del levantamiento | Único |
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| Accesibilidad | Accesible al público |
| Acceso a la información | Consulta |
| Forma de manejo | Fácil |
| Formato de la información | |
| Archivo original | 13550 |
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| Tamaño del archivo MB | |
| Cobertura | Cuenca |
| Lugar donde se produce el dato | Jalisco |
| País | Swaziland |
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